SUCCESSFUL TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE WITH EXTRACORPOREAL PHOTOPHERESIS

Authors
OWSIANOWSKI M GOLLNICK H SIEGERT W SCHWERDTFEGER R ORFANOS CE
Citation
M. Owsianowski et al., SUCCESSFUL TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE WITH EXTRACORPOREAL PHOTOPHERESIS, Bone marrow transplantation, 14(5), 1994, pp. 845-848
Citations number
12
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
14
Issue
5
Year of publication
1994
Pages
845 - 848
Database
ISI
SICI code
0268-3369(1994)14:5<845:STOCGD>2.0.ZU;2-7
Abstract
A 43-year-old woman who had undergone allogeneic bone marrow transplan t for chronic myeloid leukemia developed chronic GVHD. Despite cyclosp orine A and low-dose glucocorticoids and later concomittent PUVA-thera py, chronic GVHD with severe sclerodermatous manifestations including joint contracture and liver damage progressed. The Karnofsky performan ce score dropped to under 50%. Extracorporeal photopheresis (ECP) inst ead of PUVA-therapy was started. To our knowledge, we here report the first case of successful treatment of extensive chronic GVHD with ECP.