M. Weidenborner et Hc. Jha, STRUCTURE-ACTIVITY-RELATIONSHIPS AMONG ISOFLAVONOIDS WITH REGARD TO THEIR ANTIFUNGAL PROPERTIES, Mycological research, 98, 1994, pp. 1376-1378
In order to establish a structure-activity relationship in the class o
f isoflavonoids, 16 differently substituted isoflavonoids were tested
against Alternaria alternata, Cladosporium herbarum, Fusarium oxysporu
m and Trichoderma harzianum. The isoflavanones, 6,7-dihydroxy-4'methox
y- and 7-hydroxy-8,4'-dimethylisoflavanone showed highest antifungal a
ctivity in the case of C. herbarum as test fungus. The unreduced struc
ture of the isoflavones has less inhibitory effect on the growth of th
e test fungi, whereas the completely reduced isoflavones, i.e. the iso
flavans, showed only a very weak activity.