Ma. Azuine et Sv. Bhide, ADJUVANT CHEMOPREVENTION OF EXPERIMENTAL CANCER - CATECHIN AND DIETARY TURMERIC IN FORESTOMACH AND ORAL-CANCER MODELS, Journal of ethnopharmacology, 44(3), 1994, pp. 211-217
Catechin and dietary turmeric (Curcuma longa) were used as chemopreven
tive agents in benzo[a]pyrene induced forestomach tumors in Swiss mice
and methyl-(acetoxymethyl)-nitrosamine induced oral mucosal tumors in
Syrian golden hamsters, Catechin in drinking water and dietary turmer
ic significantly inhibited the tumor burden and tumor incidence in bot
h tumor models, The induction of oral tumors in golden hamsters was de
layed by catechin and dietary turmeric, Adjuvant chemoprevention utili
sing both catechin and dietary turmeric inhibited both the gross tumor
yield and burden more effectively than when compared to individual co
mponents in both tumor models. A single i.p. injection of catechin to
male Swiss mice induced increased forestomach and hepatic glutathione
S-transferase (GST) activity when compared to controls. These findings
suggest that catechin and turmeric which are regularly consumed natur
al products, are effective in mice or golden hamsters as chemopreventi
ve agents,