MAPPING OF THE PULMONARY SURFACTANT SP5 (SFTP2) LOCUS TO 8P21 AND CHARACTERIZATION OF A MICROSATELLITE REPEAT MARKER THAT SHOWS FREQUENT LOSS OF HETEROZYGOSITY IN HUMAN CARCINOMAS

Authors
WOOD S YAREMKO ML SCHERTZER M KELEMEN PR MINNA J WESTBROOK CA
Citation
S. Wood et al., MAPPING OF THE PULMONARY SURFACTANT SP5 (SFTP2) LOCUS TO 8P21 AND CHARACTERIZATION OF A MICROSATELLITE REPEAT MARKER THAT SHOWS FREQUENT LOSS OF HETEROZYGOSITY IN HUMAN CARCINOMAS, Genomics, 24(3), 1994, pp. 597-600
Citations number
22
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
24
Issue
3
Year of publication
1994
Pages
597 - 600
Database
ISI
SICI code
0888-7543(1994)24:3<597:MOTPSS>2.0.ZU;2-1
Abstract
We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited al lelic loss. (C) 1994 Academic Press, Inc.