Gynecomastia (enlargement of the male breast) is a common finding in p
atients seen by both primary care physicians and specialists. The pati
ent's main concerns are discomfort (if present), cosmetic alteration,
and breast cancer. For the clinician, however, a major consideration i
s the possibility that gynecomastia may be the initial presenting symp
tom of an inapparent malignancy or may be a manifestation of a serious
underlying illness. The challenge to the physician lies in separating
such patients with gynecomastia due to medical conditions requiring s
pecific treatment from the great majority of individuals with gynecoma
stia in whom there is no serious underlying pathology (Table 1).