LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33

Authors
COPEMAN JB CUCCA F HEARNE CM CORNALL RJ REED PW RONNINGEN KS UNDLIEN DE NISTICO L BUZZETTI R TOSI R POCIOT F NERUP J CORNELIS F BARNETT AH BAIN SC TODD JA
Citation
Jb. Copeman et al., LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33, Nature genetics, 9(1), 1995, pp. 80-85
Citations number
57
Categorie Soggetti
Genetics & Heredity
Journal title
Nature genetics → ACNP
ISSN journal
10614036
Volume
9
Issue
1
Year of publication
1995
Pages
80 - 85
Database
ISI
SICI code
1061-4036(1995)9:1<80:LDMOAT>2.0.ZU;2-0
Abstract
The role of human chromosome 2 in type 1 diabetes was evaluated by ana lysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. Th e microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a n ew diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserv ed synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of gene s for complex diseases.