HIGH EFFICACY OF SHORT-TERM QUININE-ANTIBIOTIC COMBINATIONS FOR TREATING ADULT MALARIA PATIENTS IN AN AREA IN WHICH MALARIA IS HYPERENDEMIC

Authors
METZGER W MORDMULLER B GRANINGER W BIENZLE U KREMSNER PG
Citation
W. Metzger et al., HIGH EFFICACY OF SHORT-TERM QUININE-ANTIBIOTIC COMBINATIONS FOR TREATING ADULT MALARIA PATIENTS IN AN AREA IN WHICH MALARIA IS HYPERENDEMIC, Antimicrobial agents and chemotherapy, 39(1), 1995, pp. 245-246
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
1
Year of publication
1995
Pages
245 - 246
Database
ISI
SICI code
0066-4804(1995)39:1<245:HEOSQC>2.0.ZU;2-V
Abstract
In a randomized trial, a three-dose quinine monotherapy was compared w ith short-term combination regimens of quinine-clindamycin and quinine -doxycycline for treating adult Gabonese patients with Plasmodium falc iparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatme nt with either combination regimen.