EFFECT OF FOOD ON ABSORPTION OF CEFPODOXIME PROXETIL ORAL SUSPENSION IN ADULTS

The effect of a high-fat meal on absorption of a 200-mg dose of cefpod oxime proxetil oral suspension was evaluated in 20 healthy, male volun teers in a randomized, two-way crossover study. The concentrations of cefpodoxime in plasma and in urine were determined by sensitive and sp ecific high-performance liquid chromatography methods. The area under the plasma drug concentration-time curve, time to peak concentration, and urinary excretion of cefpodoxime were significantly greater (P les s than or equal to 0.05) after administration of cefpodoxime proxetil oral suspension with food than under fasting conditions. However, the difference in the areas under the curve between fed and fasted treatme nts was only 11%, and application of the two one-sided tests procedure showed bioequivalence between treatments for this parameter. The slig ht increase in the extent of drug absorption and the slower rate of ab sorption which results when cefpodoxime proxetil is given with food ar e unlikely to be of clinical importance.