Mv. Shestakova et al., IBUSTRIN, A TROMBOXANE SYNTHESIS INHIBITO R, IN THE TREATMENT OF DIABETIC ANGIOPATHY, Terapevticeskij arhiv, 68(10), 1996, pp. 18-22
16 patients with insulin-dependent diabetes mellitus (IDDM) lasting 8-
19 years had pronounced diabetic nephropathy (proteinuria stage), reti
nopathy (stage I, II or III), disturbed circulation in the lower limbs
detected at foot dopplerography. For 3 months these patients received
ibustrin (inhibitor of cyclooxigenase, blocker of tromboxane A2 synth
esis and platelet aggregation) before renal function underwent positiv
e changes: glomerular filtration rate increased in 13 patients (81%),
24-h proteinuria decreased in 12 patients (75%). Retinal vascular cond
ition improved in 5 of 6 patients with nonproliferative retinopathy an
d in 2 of 5 patients with preproliferative retinopathy, in 1 and 3 pat
ients stabilization occurred, respectively. In proliferative retinopat
hy improvement and stabilization were registered in 1 and 3 of 5 patie
nts, respectively. According to feet artery dopplerography the improve
ment, no changes and moderate aggravation occurred in 10(62%), 3(19%)
and 3(19%) of patients, respectively. The conclusion is made that ibus
trin effectively inhibits progression of IDDM vascular complications,
especially at early angiopathy stages.