When the patent on a drug expires, there are substantial welfare gains
to those consumers who, like the Food and Drug Administration, regard
branded and generic versions as perfect substitutes. Standard price i
ndexes fail to reflect this, since they treat generics as distinct new
goods and ''link them in'' with fixed weights. Alternative calculatio
ns are presented, using detailed data on the wholesale prices of two a
nti-infective drugs. Significant differences are found: for one of the
drugs studied the standard price index rose by 14 percent over 45 mon
ths following patent expiration, while our preferred alternative index
fell by 48 percent.