PLATELET DISORDERS IN GRAVIDAE WITH CHRON IC GLOMERULONEPHRITIS (CGN)AND ESSENTIAL-HYPERTENSION (EH)

To assess platelet changes in pregnant women with chronic glomerulonep hritis (CGN) and essential hypertension (EH) we estimated platelet lac tic dehydrogenase activity (LDH), beta-thromboglobulin and thromboxane B-2 (TxB(2)) plasma levels and ADP-stimulated platelet aggregability. Five groups of gravidae (26-40 weeks of gestation) were studied: with EH (n=20), with CGN and hypertension (n=31), with CGN without hyperte nsion (n=29), with late toxemia (n=11), nonpregnant CGN women (n=10) a nd healthy pregnant women (n=20). Activation of platelet function was found in gravidae with CGN and EH. Platelet disorders were especially pronounced in pregnant women with CGN and with EH, but they were less pronounced than in control group with late toxemia. We believe that hy pertension is more important stimulating factor for platelet activatio n than renal disease. We suggest that platelet disorders in outpatient s are brought about by endothelium damage caused by elevated blood pre ssure.