EXPRESSION OF THE ARP PROTEIN, A MEMBER OF THE M-PROTEIN FAMILY, IS NOT SUFFICIENT TO INHIBIT PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES

Citation
Lk. Husmann et al., EXPRESSION OF THE ARP PROTEIN, A MEMBER OF THE M-PROTEIN FAMILY, IS NOT SUFFICIENT TO INHIBIT PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES, Infection and immunity, 63(1), 1995, pp. 345-348
Citations number
38
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
ISSN journal
00199567
Volume
63
Issue
1
Year of publication
1995
Pages
345 - 348
Database
ISI
SICI code
0019-9567(1995)63:1<345:EOTAPA>2.0.ZU;2-J
Abstract
Many Streptococcus pyogenes immunoglobulin-binding proteins have struc tural similarities to the antiphagocytic M protein, including the well -known C repeats. One of these molecules is the immunoglobulin A-bindi ng protein Arp, which is expressed by a serotype 4 strain for which no antiphagocytic M protein has yet been described. We expressed Arp4 in an S. pyogenes strain from which the structural gene for the M protei n has been deleted and found that Arp4 is not sufficient to inhibit ph agocytosis.