Lk. Husmann et al., EXPRESSION OF THE ARP PROTEIN, A MEMBER OF THE M-PROTEIN FAMILY, IS NOT SUFFICIENT TO INHIBIT PHAGOCYTOSIS OF STREPTOCOCCUS-PYOGENES, Infection and immunity, 63(1), 1995, pp. 345-348
Many Streptococcus pyogenes immunoglobulin-binding proteins have struc
tural similarities to the antiphagocytic M protein, including the well
-known C repeats. One of these molecules is the immunoglobulin A-bindi
ng protein Arp, which is expressed by a serotype 4 strain for which no
antiphagocytic M protein has yet been described. We expressed Arp4 in
an S. pyogenes strain from which the structural gene for the M protei
n has been deleted and found that Arp4 is not sufficient to inhibit ph
agocytosis.