IMMUNIZATION OF CATTLE WITH RECOMBINANT BABESIA-BOVIS MEROZOITE SURFACE ANTIGEN-1

Authors
HINES SA PALMER GH JASMER DP GOFF WL MCELWAIN TF
Citation
Sa. Hines et al., IMMUNIZATION OF CATTLE WITH RECOMBINANT BABESIA-BOVIS MEROZOITE SURFACE ANTIGEN-1, Infection and immunity, 63(1), 1995, pp. 349-352
Citations number
39
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
1
Year of publication
1995
Pages
349 - 352
Database
ISI
SICI code
0019-9567(1995)63:1<349:IOCWRB>2.0.ZU;2-V
Abstract
Cattle immunized with a recombinant merozoite surface antigen-1 molecu le (MSA-1) produced high-titered antibody that reacted with the surfac e of the parasite and neutralized merozoite infectivity in vitro. Howe ver, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that ant ibody-mediated neutralization of merozoite infectivity in vitro, at le ast for MSA-1-specific antibody, does not reflect in vivo protective i mmunity to babesiosis.