ROLE OF DNA-PLOIDY AND ERB-B2 ONCOGENE EXPRESSION IN THE PROGNOSIS OFENDOMETRIAL CARCINOMA

Seventy-three patients with endometrial carcinoma have been retrospect ively evaluated in this paper Stage, grade, depth of myometrial invasi on, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immun ohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stag e and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation b etween depth of myometrial invasion and survival was found. Besides, i t has been shown that tumours with ERB-B2 oncogene hyperexpression see m to have a more aggressive evolution.