SYNTHESIS OF SPHINGOSINE-1-PHOSPHATE AND DIHYDROSPHINGOSINE-1-PHOSPHATE

Authors
BOUMENDJEL A MILLER SPF
Citation
A. Boumendjel et Spf. Miller, SYNTHESIS OF SPHINGOSINE-1-PHOSPHATE AND DIHYDROSPHINGOSINE-1-PHOSPHATE, Journal of lipid research, 35(12), 1994, pp. 2305-2311
Citations number
35
Categorie Soggetti
Biology
Journal title
Journal of lipid research → ACNP
ISSN journal
00222275
Volume
35
Issue
12
Year of publication
1994
Pages
2305 - 2311
Database
ISI
SICI code
0022-2275(1994)35:12<2305:SOSAD>2.0.ZU;2-P
Abstract
The syntheses of D-erythro-sphingosine-1-phosphate ate and DL-erythro- sphinganine-1-phosphate are described starting from the commercially a vailable D-erythro-sphingosine and DL-erythro-sphinganine. The phospha te group is introduced via phosphoramidite chemistry using 2-cyanoethy l)-N,N-diisopropylamino-phosphoramidite as the monophosphorylating rea gent. The procedure generates the phosphorylated sphingoid bases in th ree steps and 32-39% overall yields.