SELF-DETERMINANTS IN AUTOIMMUNE DEMYELINATING DISEASE - CHANGES IN T-CELL RESPONSE SPECIFICITY

Authors
TUOHY VK FRITZ RB BENNUN A
Citation
Vk. Tuohy et al., SELF-DETERMINANTS IN AUTOIMMUNE DEMYELINATING DISEASE - CHANGES IN T-CELL RESPONSE SPECIFICITY, Current opinion in immunology, 6(6), 1994, pp. 887-891
Citations number
48
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
6
Issue
6
Year of publication
1994
Pages
887 - 891
Database
ISI
SICI code
0952-7915(1994)6:6<887:SIADD->2.0.ZU;2-F
Abstract
Recent research developments support the following views regarding ant igen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants fr om multiple myelin proteins can be recognized; target determinant epit opes may differ among individuals; and target epitope recognition can change with time during the course of disease.