GENETIC AND PATHOGENIC BASIS OF AUTOIMMUNE DIABETES IN NOD MICE

Authors
SERREZE DV LEITER EH
Citation
Dv. Serreze et Eh. Leiter, GENETIC AND PATHOGENIC BASIS OF AUTOIMMUNE DIABETES IN NOD MICE, Current opinion in immunology, 6(6), 1994, pp. 900-906
Citations number
62
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
6
Issue
6
Year of publication
1994
Pages
900 - 906
Database
ISI
SICI code
0952-7915(1994)6:6<900:GAPBOA>2.0.ZU;2-S
Abstract
Non-obese diabetic (NOD) mice are an excellent model of T-cell mediate d autoimmune insulin-dependent diabetes in humans. Recent studies in N OD mice have shown that this disease is a result of epistatic interact ions between multiple genes, both inside and outside the major histoco mpatibility complex (MHC), generating T cells reactive against an expa nding repertoire of autoantigens.