APOPTOSIS, FAS AND SYSTEMIC AUTOIMMUNITY - THE MRL-IPR IPR MODEL/

Authors
SINGER GG CARRERA AC MARSHAKROTHSTEIN A MARTINEZA C ABBAS AK
Citation
Gg. Singer et al., APOPTOSIS, FAS AND SYSTEMIC AUTOIMMUNITY - THE MRL-IPR IPR MODEL/, Current opinion in immunology, 6(6), 1994, pp. 913-920
Citations number
66
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
6
Issue
6
Year of publication
1994
Pages
913 - 920
Database
ISI
SICI code
0952-7915(1994)6:6<913:AFASA->2.0.ZU;2-O
Abstract
Proteins encoded by the fas and fas ligand (fasL) genes are involved i n apoptotic cell death in lymphocytes. In this article we review the r ecent elucidation of the role of the Fas-FasL interactions in the main tenance of tolerance to self antigens and in the homeostatic regulatio n of lymphocyte clonal expansion, and discuss the mechanisms of autoim munity in Fas- and FasL-deficient mutant mouse strains.