THE VARIOUS CLINICAL-PATTERNS OF XANTHOMA DISSEMINATUM - CONSIDERATIONS ON 7 CASES AND REVIEW OF THE LITERATURE

Background: Xanthoma disseminatum (XD) is a rare mucocutaneous xanthom a nowadays classified as a benign non-langerhans cell histiocytosis. O bjective: We studied 7 cases of XD with a long follow-up and reviewed the Literature in order to compare and discuss previous reports. Metho ds: We studied clinical manifestations, course, histopathologic, ultra structural and immunohistochemical findings of 7 cases of XD followed for 1-20 years, Results: We report our findings and compare our cases with those described in the literature. Conclusions: XD and Langerhans cell histiocytosis were distinguished by clinical differences, as wel l as ultrastructural and immunohistochemical methods. Three clinical p atterns of XD appeared to emerge in our group of patients and in the c ases reviewed from the literature.