EVALUATION OF TETRACYCLINE RAW-MATERIALS AND FINISHED PRODUCTS FOUND ON THE KENYAN MARKET

Contents of tetracycline, its degradation products (epitetracycline, e pianhydrotetracycline, anhydrotetracycline) and a fermentation impurit y (2-acetyl-2-decarboxamidotetracycline) were determined in four raw m aterials, 12 batches of six ointment products, four eye ointment produ cts and nine batches of five capsule products, all sampled from the Ke nyan market. The analytical method was liquid chromatography on a colu mn packed with,a poly(styrenedivinylbenzene) material (8-mu m PLRP-S 1 00 Angstrom). All raw materials and finished products had tetracycline contents and impurity levels within the prescribed compendial limits.