EFFECTS OF DRUG-BINDING ON THE THERMAL-DENATURATION OF HUMAN SERUM-ALBUMIN

Asymmetric thermograms of defatted albumin, alone and in the presence of two model drugs, have been obtained in phosphate buffers at three p H values. The albumin is less thermally stable in the N form, but is p rotected by both drugs. The nonsteroidal antiinflammatory benoxaprofen offers more protection than warfarin against thermal denaturation.