CHIRAL DISCRIMINATION OF PHENETHYLAMINES WITH BETA-CYCLODEXTRIN AND HEPTAKIS(2,3-DI-O-ACETYL)BETA-CYCLODEXTRIN BY CAPILLARY ELECTROPHORESISAND NMR-SPECTROSCOPY

The resolution of nine sympathomimetic phenethylamine racemates by bet a-cyclodextrin and heptakis(2,3-di-O-acetyl)beta-cyclodextrin has been investigated by capillary electrophoresis and H-1 NMR spectroscopy. T he NMR and capillary electrophoresis results showed that beta-cyclodex trin probably formed stronger complexes with the amines than did hepta kis(2,3-di-O-acetyl)beta-cyclodextrin but was a poorer chiral discrimi nation agent in both techniques. The addition of heptakis(2,3-di-O-ace tyl)beta-cyclodextrin to the capillary electrophoresis buffer gave bas eline resolution of enantiomer peaks for seven of the compounds studie d while beta-cyclodextrin resolved only three of the racemates.