OVEREXPRESSION OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE IN XENOPUS OOCYTES INHIBITS AGONIST-EVOKED CAPACITATIVE CALCIUM-ENTRY

Authors
VERJANS B PETERSEN CCH BERRIDGE MJ
Citation
B. Verjans et al., OVEREXPRESSION OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE IN XENOPUS OOCYTES INHIBITS AGONIST-EVOKED CAPACITATIVE CALCIUM-ENTRY, Biochemical journal, 304, 1994, pp. 679-682
Citations number
28
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
304
Year of publication
1994
Part
3
Pages
679 - 682
Database
ISI
SICI code
0264-6021(1994)304:<679:OOI13I>2.0.ZU;2-U
Abstract
Ins(1,4,5)P-3 3-kinase is a key enzyme in the regulation of Ins(1,4,5) P-3. Overexpression of Ins(1,4,5)P-3 3-kinase inhibited agonist-evoked and Ins(1,3,4,5)P-4-evoked Ca2+ entry in Xenopus oocytes, but did not inhibit Ca2+ entry evoked by thapsigargin or non-metabolizable Ins(1, 4,5)P-3 analogues. The data suggest that Ins(1,4,5)P-3 alone plays the crucial role in the activation of capacitative Ca2+ entry by emptying intracellular stores.