T-LYMPHOCYTE-MEDIATED ANTIVIRAL IMMUNE-RESPONSES IN MICE ARE DIMINISHED BY TREATMENT WITH MONOCLONAL-ANTIBODY DIRECTED AGAINST THE INTERLEUKIN-2 RECEPTOR
O. Utermohlen et al., T-LYMPHOCYTE-MEDIATED ANTIVIRAL IMMUNE-RESPONSES IN MICE ARE DIMINISHED BY TREATMENT WITH MONOCLONAL-ANTIBODY DIRECTED AGAINST THE INTERLEUKIN-2 RECEPTOR, European Journal of Immunology, 24(12), 1994, pp. 3093-3099
Blocking the interleukin-2 receptor's alpha-chain in lymphocytic chori
omeningitis virus-infected mice by treatment with monoclonal antibodie
s diminished the increase of numbers of CD8(+) T lymphocytes in spleen
s and prevented CD8(+) T lymphocyte-mediated virus clearance from orga
ns as well as generation of virus-specific cytotoxic T lymphocytes. Al
so, the CD8(+) T cell-mediated early phase of the delayed-type hyperse
nsitivity footpad swelling reaction was decreased. The same treatment
had no effect on the number of CD4(+) spleen T lymphocytes, which, how
ever, did not enlarge during infection, but these cells' heightened DN
A synthesis and cytokine production were reduced by antibody treatment
; yet the generation of antiviral antibodies remained unaffected, and
the CD4(+) T lymphocyte-mediated second part of the footpad reaction w
as somewhat augmented. We conclude that blocking of the interleukin-2
receptor by antibody in lymphocytic choriomeningitis virus-infected mi
ce diminishes both CD8(+) and CD4(+) T cell-mediated antiviral immune
responses, the former more than the latter.