ANTIMALARIAL AGENTS - ARE WE RUNNING OUT OF OPTIONS

The world faces the growing problem of multidrug-resistant Plasmodium falciparum, and chloroquine and primaquine-resistant Plasmodium vivax. Despite a seemingly large armamentarium of antimalarial drugs with va rious molecular targets, there are no regimens for the prevention or t reatment of infection that are without some failures or some potential toxicity. Recommended chemoprophylactic regimens vary and controversy persists regarding their safety and efficacy. Furthermore, funding fo r malaria control and drug development has diminished. The wise use of available agents and the support of collaborative research efforts ar e necessary to address the problem of multidrug resistance and to deve lop novel approaches to malaria prevention and treatment. This review will focus on the recommended regimens for chemoprophylaxis of P. falc iparum, and some of the newer agents and alternative strategies used f or treatment.