Tumors arising from veins are rare, usually present with nonspecific c
linical and imaging findings and almost universally show histology of
leiomyosarcoma. This twentieth reported case of primary renal vein lei
omyosarcoma demonstrates invasion of the renal vein with endoluminal p
ropagation of tumor into the infrahepatic inferior vena cava (IVC), an
unreported manifestation. The combination of CT, ultrasound, and angi
ographic studies allowed differentiation from renal cell carcinoma by
suggesting a tumor arising from the renal vein.