Multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic
vascular tumor with distinctive histologic features. It appears clini
cally as small, slow-growing, grouped reddish-brown to purple papules
and nodules that may be mistaken for other vascular proliferative or r
eactive conditions. Multinucleate cell angiohistiocytoma tends to occu
r more frequently in women, to favor the extremities, and to appear as
multiple lesions. We report a case of a solitary multinucleate cell a
ngiohistiocytoma that appeared as a nodule on the upper lip of a man b
ut that otherwise demonstrated characteristic histologic and immunohis
tochemical features. Greater awareness of this uncommon benign lesion
will facilitate diagnosis and appropriate management.