The central odontogenic fibroma is a rare benign neoplasm that is cons
idered to be derived from mesenchymal dental tissue. This study review
s and analyzes the radiologic features of 51 cases (5 new cases and 46
from the literature). Central odontogenic fibroma appears in both the
mandible and maxilla (55% and 45%, respectively). In the maxilla it h
as a tendency to involve the anterior area, whereas in the mandible th
e molar and premolar areas are the most prevalent sites. The majority
of central odontogenic fibromas are unilocular radiolucent lesions wit
h well-defined borders, but they may also appear as multilocular lesio
ns and in rare instances may exhibit a mixed radiolucent/radiopaque ap
pearance with poorly defined or diffused borders. The great variabilit
y in radiologic appearance of the central odontogenic fibroma means th
at it shoudl be considered in the differential diagnosis of all radiol
ucencies found in the jaws.