ASSOCIATION OF CASTLEMAN-DISEASE AND HODG KINS-DISEASE - REPORT OF 8 CASES WITH REVIEW OF LITERATURE

We have recorded 8 patients presenting a Hodgkin's disease associated with Castleman's disease. Four men and 4 women with a 44 years mean ag e (15-60), presented as a solitary mass (2/7) or as a multicentric tum oral disease (5/7). One of our patients was HIV. Histological studies showed typical features of Castleman's disease. Nodular sclerosing Hod gkin's disease with numerous lacunar cells were present in 3 cases, in terfollicular Hodgkin's disease in 4 cases and nodular paragranuloma i n one cazse. Hodgkins' and Reed Sternberg cells were positive for CD15 (4/7), CD30 (5/7), EMA (3/6) and LMP-1 (4/5). In situ hybridization o n tissue sections demonstr ate presence of EBV DNA in one case and EBE R1-RNA in 2 of 4 cases. The difficulty in making the diagnosis of Hodg kin's disease the relation between both diseases, and the role of IL-6 are discussed.