V. Patinec et al., MONO N-ALKYLATION AND N-ACYLATION OF CYCLEN AND CYCLAM VIA THEIR METALTRICARBONYL COMPLEXES (M=CR, MO), Tetrahedron letters, 36(1), 1995, pp. 79-82
Reaction of metaltricarbonyl complexes of cyclen and cyclam with enoli
sable aldehydes or acid chlorides yields, after removal of the protect
ing M(CO)(3) moiety, selectively mono N-functionalized derivatives.