STEREOCONTROLLED ALDOL ADDITIONS TO ALPHA-METHYLENE-BETA-ALKOXY ALDEHYDES - APPLICATION TO THE SYNTHESIS OF A C-13-C-25 SEGMENT OF BAFILOMYCIN A(1)

Authors
PATERSON I BOWER S MCLEOD MD
Citation
I. Paterson et al., STEREOCONTROLLED ALDOL ADDITIONS TO ALPHA-METHYLENE-BETA-ALKOXY ALDEHYDES - APPLICATION TO THE SYNTHESIS OF A C-13-C-25 SEGMENT OF BAFILOMYCIN A(1), Tetrahedron letters, 36(1), 1995, pp. 175-178
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
1
Year of publication
1995
Pages
175 - 178
Database
ISI
SICI code
0040-4039(1995)36:1<175:SAATAA>2.0.ZU;2-0
Abstract
A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehy de 9, followed by directed hydrogenation at C-16 and acetonide hydroly sis, gives the C-13-C-25 segment 6 of bafilomycin A(1).