CHROMOSOMAL POSITION EFFECTS AND THE MODULATION OF TRANSGENE EXPRESSION

Authors
CLARK AJ BISSINGER P BULLOCK DW DAMAK S WALLACE R WHITELAW CBA YULL F
Citation
Aj. Clark et al., CHROMOSOMAL POSITION EFFECTS AND THE MODULATION OF TRANSGENE EXPRESSION, Reproduction, fertility and development, 6(5), 1994, pp. 589-598
Citations number
49
Categorie Soggetti
Reproductive Biology","Developmental Biology
Journal title
Reproduction, fertility and development → ACNP
ISSN journal
10313613
Volume
6
Issue
5
Year of publication
1994
Pages
589 - 598
Database
ISI
SICI code
1031-3613(1994)6:5<589:CPEATM>2.0.ZU;2-1
Abstract
Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencie s and levels of gene expression and, in some cases, in aberrant patter ns of expression. Strategies for overcoming these effects are describe d with particular reference to their application in embryonic stem cel ls.