AMLODIPINE IN STABLE EXERTIONAL ANGINA - RESULTS OF A MULTICENTER TRIAL

Amlodipine, a recently developed calcium channel antagonist of the dih ydropyridine family, is indicated both for the prevention of stable an gina and for the treatment of arterial hypertension, in the same dosag e. The efficacy of amlodipine in angina was investigated in a multicen ter trial conducted in 22 cardiology departments in France. Tolerance to exercise was improved 60 days after initiation of the drug. Analysi s of stress electrocardiogram parameters at the end of the study demon strated significant improvements versus baseline in the ischemia thres hold (+ 21.8%), time to ischemia (+ 31%), and maximum exercise capacit y (+ 9.7%). Overall, safety data were highly satisfactory.