CASTING SOLVENT CONTROLLED-RELEASE OF CHLORHEXIDINE FROM ETHYLCELLULOSE FILMS PREPARED BY SOLVENT EVAPORATION

Authors
JONES DS MEDLICOTT NJ
Citation
Ds. Jones et Nj. Medlicott, CASTING SOLVENT CONTROLLED-RELEASE OF CHLORHEXIDINE FROM ETHYLCELLULOSE FILMS PREPARED BY SOLVENT EVAPORATION, International journal of pharmaceutics, 114(2), 1995, pp. 257-261
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
114
Issue
2
Year of publication
1995
Pages
257 - 261
Database
ISI
SICI code
0378-5173(1995)114:2<257:CSCOCF>2.0.ZU;2-T
Abstract
Chlorhexidine release from ethylcellulose films east from solvents of different dichloromethane/ethanol compositions was studied. Release ra te was proportional to the square root of time. Increased ethanol cont ent within the casting solvent significantly enhanced release rate. Re lease rate and cumulative mass released at different time periods (5, 10, 15 and 25 days) were proportional to the solubility parameter of t he casting solvent.