STUDIES ON THE PREPARATION OF BIOACTIVE LIGNANS BY OXIDATIVE COUPLINGREACTION .1. PREPARATION AND LIPID-PEROXIDATION INHIBITORY EFFECT OF BENZOFURAN LIGNANS RELATED TO SCHIZOTENUINS

Authors
MAEDA S MASUDA H TOKOROYAMA T
Citation
S. Maeda et al., STUDIES ON THE PREPARATION OF BIOACTIVE LIGNANS BY OXIDATIVE COUPLINGREACTION .1. PREPARATION AND LIPID-PEROXIDATION INHIBITORY EFFECT OF BENZOFURAN LIGNANS RELATED TO SCHIZOTENUINS, Chemical and Pharmaceutical Bulletin, 42(12), 1994, pp. 2500-2505
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
12
Year of publication
1994
Pages
2500 - 2505
Database
ISI
SICI code
0009-2363(1994)42:12<2500:SOTPOB>2.0.ZU;2-Y
Abstract
The parent benzofuran lignan 4 of schizotenuins 1-3 and related compou nds were efficiently prepared by a judicious use of the oxidative coup ling reaction, and were tested for their inhibitory effects on lipid p eroxidation in rat brain homogenate and rat liver microsomes. Among tw elve compounds tested in rat brain homogenate, compounds 13, 14 and 16 showed prominent inhibitory activity. Compounds 13 and 16 were then t ested in rat liver microsomes, and their activity was found to be more potent than schizotenuin A (1) and much more potent than that of (+/- )-alpha-tocopherol.