STUDY ON PHARMACOLOGICAL EFFECT OF BILE-SALTS, SODIUM SCYMNOL SULFATE, FROM RHIZOPRIONODON ACUTUS .1. EFFECT OF SCYMNOL, CHIMAEROL AND SODIUM SCYMNOL SULFATE ON CEREBRAL ANOXIA

The effects of scymnol, chimaerol and sodium scymnol sulfate, prepared from the bile of Rhizoprionodon acutus, on cerebral anoxia were inves tigated in experimental models of hypoxia, ischemia and histotoxic ano xia in mice. Scymnol, at a dose of 100 mg/kg, showed a significant pro tective action against cerebral anoxia in all of the models studied an d significantly increased the partial oxygen pressure of the arterial blood. The anti-anoxic activity of scymnol was found to be slightly gr eater than that of idevenone. A similar protective effect of sodium sc ymnol sulfate was seen at doses higher than 100 mg/kg. The survival ti me on hypoxia was significantly prolonged in the animals pretreated wi th chimaerol.