SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS - THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS

Authors
YOSHIKAWA M YOKOKAWA Y OKUNO Y YAGI N MURAKAMI N
Citation
M. Yoshikawa et al., SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS - THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS, Chemical and Pharmaceutical Bulletin, 42(12), 1994, pp. 2662-2664
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
12
Year of publication
1994
Pages
2662 - 2664
Database
ISI
SICI code
0009-2363(1994)42:12<2662:SONIMA>2.0.ZU;2-8
Abstract
Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and no r-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, w ere synthesized from 2-deoxy-D-glucose via common intermediates in pre vious myriocin and Z-myriocin syntheses. The immunosuppressive activit ies of new myriocin analogs and Z-myriocin on mouse allogeneic mixed l ymphocyte reaction were examined, and, by comparing with those of myri ocin and 14-deoxomyriocin, some structure-activity relationships have been found.