SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS - THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS
M. Yoshikawa et al., SYNTHESES OF NEW IMMUNOSUPPRESSIVE MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS - THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS, Chemical and Pharmaceutical Bulletin, 42(12), 1994, pp. 2662-2664
Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and no
r-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, w
ere synthesized from 2-deoxy-D-glucose via common intermediates in pre
vious myriocin and Z-myriocin syntheses. The immunosuppressive activit
ies of new myriocin analogs and Z-myriocin on mouse allogeneic mixed l
ymphocyte reaction were examined, and, by comparing with those of myri
ocin and 14-deoxomyriocin, some structure-activity relationships have
been found.