RECOMBINANT SOLUBLE FC-GAMMA RECEPTORS - PRODUCTION, PURIFICATION ANDBIOLOGICAL-ACTIVITIES

Soluble forms of low affinity receptors for the Fe portion of IgG circ ulate in body fluids and regulate immune functions. We describe the tr ansfection, production and purification techniques which allow the pre paration, at a laboratory scale, of milligram amounts of glycosylated recombinant mouse and human soluble Fc gamma receptors. These recombin ant products bind IgG and are biologically active on immune responses, like their normal counterparts.