A SUSCEPTIBILITY GENE FOR ALVEOLAR LUNG-TUMORS IN THE MOUSE MAPS BETWEEN HSP70.3 AND G7 WITHIN THE H2 COMPLEX

Lung tumor susceptibility (LTS) in the mouse is influenced by multiple loci within the H2 complex. We compared the LTS of two H2 congenic st rains with intra H2 recombinations, B10.A(1R) and B10.A(2R), whose gen etic difference has been reduced to a region of approximately 50 kilob ases within the C4-H2D interval, between Hsp70.3 and G7. After transpl acental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10.A(2R) is significantly higher than in strain B10 .A(1R) (P <0.001). For papillary tumors no significant differences wer e observed. We conclude that the alveolar lung tumor load is influence d by an LTS gene located within the Hsp70.3-G7 interval.