DIFFERENCES IN THE CELLULAR-RESPONSE OF T HE IMMUNE-SYSTEM IN PATIENTS WITH PAGETS-DISEASE OF THE BONE AFTER ADMINISTRATION OF ELCATONIN AND ETIDRONATE

Authors
RAPADO A GAVILANES EL PALOMINO P YAGUE M DELAPIEDRA C CURIEL MD ORTIZ F
Citation
A. Rapado et al., DIFFERENCES IN THE CELLULAR-RESPONSE OF T HE IMMUNE-SYSTEM IN PATIENTS WITH PAGETS-DISEASE OF THE BONE AFTER ADMINISTRATION OF ELCATONIN AND ETIDRONATE, Revista Clinica Espanola, 194(11), 1994, pp. 970-973
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista Clinica Espanola → ACNP
ISSN journal
00142565
Volume
194
Issue
11
Year of publication
1994
Pages
970 - 973
Database
ISI
SICI code
0014-2565(1994)194:11<970:DITCOT>2.0.ZU;2-#
Abstract
A cellular immunological defect is present in patients with Paget's di sease of the bone. Low counts of CD4, high counts of CD8, and a low CD 4/CD8 ratio were observed in 58 patients compared with controls. These findings were not correlated with the metabolic activity of the disea se. After therapy with Elcatonine an improvement in the cellular immun ological defect was observed in 15 patients. Etidronate improved the b iochemical bone patterns but no changes were observed in the number of lymphocytic subpopulations. These changes can be related to the impro vement in the bone metabolic disorder or be the result of an efect on the altered immunity in this disease.