Bg. Chittim et al., COMPARISON OF GC-MS WITH AN IN-VITRO BIOASSAY FOR PCDDS AND RELATED-COMPOUNDS IN ENVIRONMENTAL-SAMPLES, Chemosphere, 29(9-11), 1994, pp. 1783-1788
An assay for dioxin-like compounds in environmental matrices was devel
oped, based on the competitive association of the sample and a fixed a
liqout of radiolabelled TCDD for a fixed aliquot of Ah receptor obtain
ed from C57BL/6 mouse liver. Results obtained using the receptor-based
assay were compared with those obtained by CC-MS; the extent to which
extensive chromatographic clean-up of the sample was required prior t
o the receptor-based assay was also determined.