MUTAGENIC AND CARCINOGENIC RISK OF OXYGEN-CONTAINING CHLORINATED C-3 HYDROCARBONS - PUTATIVE SECONDARY PRODUCTS OF C-3 CHLOROHYDROCARBONS AND CHLORINATION OF WATER

Authors
EDER E WEINFURTNER E
Citation
E. Eder et E. Weinfurtner, MUTAGENIC AND CARCINOGENIC RISK OF OXYGEN-CONTAINING CHLORINATED C-3 HYDROCARBONS - PUTATIVE SECONDARY PRODUCTS OF C-3 CHLOROHYDROCARBONS AND CHLORINATION OF WATER, Chemosphere, 29(9-11), 1994, pp. 2455-2466
Citations number
43
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
29
Issue
9-11
Year of publication
1994
Pages
2455 - 2466
Database
ISI
SICI code
0045-6535(1994)29:9-11<2455:MACROO>2.0.ZU;2-W
Abstract
Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water. These compounds a re mutagenic, genotoxic and carcinogenic. 2-Chloroacroleins are extrem ely strong mutagens and genotoxins and form 1,N2(-)cyclic deoxyguanosi ne adducts. The role of such adducts in mutagenicity and carcinogenici ty is discussed.