A COMPARISON OF DEMINERALIZED FREEZE-DRIED BONE AND AUTOLOGOUS BONE TO INDUCE BONE-FORMATION IN HUMAN EXTRACTION SOCKETS

THE PURPOSE OF THIS STUDY WAS TO test the bone-forming capacity of dem ineralized freeze-dried bone (DFDBA) and autologous bone grafts in ext raction sockets. Seven paired sites were grafted with either DFDBA or autologous bone. The sites were reentered between 3 and 13 months for the purposes of obtaining biopsies of the grafted sites and to place e ndosseous implants. Biopsies from 6 of the 7 grafted sites were evalua ted for new bone formation. DFDBA sites revealed the presence of dead particles of DFDBA with no evidence of bone formation on the surfaces of the implanted particles and no evidence of osteoclastic resorption of the bone particles. Biopsies from the 6 autologous sites revealed v ascular channels with woven and lamellar bone. Some specimens had reta ined cortical, non-vital bone chips. These bone chips were undergoing active osteoclastic resorption. The results of this study questions th e use of DFDBA as a bone inductive graft material.