STRATEGIES FOR DATABASE DEREPLICATION OF NATURAL-PRODUCTS

The rapid characterization of known compounds (dereplication) has beco me an important consideration for the natural products chemise screeni ng for pharmaceutical or agricultural compounds. Several commercial da tabases have been developed to assist the chemist in identifying known compounds with minimal amounts of physical or biological data. Strate gies have been developed to efficiently search STN (Scientific and Tec hnical Network) files with formula weight, carbon count, structure fra gments, bioactivity, and taxonomy. A brief review is also provided on other commercially available databases that are useful for natural pro ducts dereplication.