PREVENTIVE EFFECT OF ULINASTATIN ON RENAL SCARRING IN RAT MODEL OF PYELONEPHRITIS INDUCED BY DIRECT OR ASCENDING INFECTION WITH SERRATIA-MARCESCENS OR ESCHERICHIA-COLI

Renal scarring is considered to be a characteristic of reflux nephropa thy. The effects of ulinastatin, a strong inhibitor of polymorphonucle ar leukocyte elastase, on renal scarring following direct parenchymal or intravesical ascending infection by Serratia marcescens or Escheric hia coli were determined. Four days of treatment with ulinastatin init iated 2 or 5 days after infection prevented renal scarring. Doses of 1 ,000-4,000 units/kg inhibited renal scar formation, but 8,000 units/kg did not. These results suggest that it may be possible to limit renal scar formation in pyelonephritis by the use of an appropriate pharmac ologic agent.