[H-3] THYMIDINE UPTAKE AND LIPID-PEROXIDATION BY TUMOR-CELLS ON EMBELIN TREATMENT - AN IN-VITRO STUDY

Using a rapid technique to assess drug-induced cell toxicity, a fibros arcoma cell line was exposed in vitro to increasing concentrations of embelin, a benzoquinone derivative of Embelia ribes Burm., and simulta neously inoculated with [H-3]-thymidine. After regular time intervals, the cells were examined for incorporation of the labelled thymidine i n DNA, lipid peroxide and glutathione levels. A dose-dependent decreas e in labelled thymidine uptake, lipid peroxide and glutathione levels was observed on embelin administration.