BIOCOMPATIBILITY OF A HEPARIN-BONDED MEMBRANE-OXYGENATOR (CARMEDA MAXIMA) DURING THE FIRST 90 MINUTES OF CARDIOPULMONARY BYPASS - CLINICAL COMPARISON WITH THE CONVENTIONAL SYSTEM

Authors
SHIGEMITSU O HADAMA T TAKASAKI H MORI Y KIMURA T MIYAMOTO S SAKO H SOEDA T KAWAWAKI Y UCHIDA Y
Citation
O. Shigemitsu et al., BIOCOMPATIBILITY OF A HEPARIN-BONDED MEMBRANE-OXYGENATOR (CARMEDA MAXIMA) DURING THE FIRST 90 MINUTES OF CARDIOPULMONARY BYPASS - CLINICAL COMPARISON WITH THE CONVENTIONAL SYSTEM, Artificial organs, 18(12), 1994, pp. 936-941
Citations number
11
Categorie Soggetti
Engineering, Biomedical
Journal title
Artificial organs → ACNP
ISSN journal
0160564X
Volume
18
Issue
12
Year of publication
1994
Pages
936 - 941
Database
ISI
SICI code
0160-564X(1994)18:12<936:BOAHM(>2.0.ZU;2-U
Abstract
We clinically compared a heparin-bonded Carmeda MAXIMA membrane oxygen ator to a nonheparin-bonded MAXIMA in 20 patients undergoing coronary artery bypass grafting or valve replacement. Reductions of fibrinogen, factor XII, and high molecular weight kininogen were greater in the M AXIMA group. Serum C3a and free hemoglobin were lower in the Carmeda g roup. The level of C4a, though remarkably lower than that of C3a, was higher in the Carmeda group then in the MAXIMA group. Both oxygenators performed well in terms of blood gas exchange. We conclude that the h eparin-bonded Carmeda oxygenator offers superior biocompatibility duri ng cardiopulmonary bypass.