3 ISOFORMS OF PLATELET-DERIVED GROWTH-FACTORS ALL HAVE THE CAPABILITYTO INDUCE ANGIOGENESIS IN-VIVO

Authors
OIKAWA T ONOZAWA C SAKAGUCHI M MORITA I MUROTA S
Citation
T. Oikawa et al., 3 ISOFORMS OF PLATELET-DERIVED GROWTH-FACTORS ALL HAVE THE CAPABILITYTO INDUCE ANGIOGENESIS IN-VIVO, Biological & pharmaceutical bulletin, 17(12), 1994, pp. 1686-1688
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
17
Issue
12
Year of publication
1994
Pages
1686 - 1688
Database
ISI
SICI code
0918-6158(1994)17:12<1686:3IOPGA>2.0.ZU;2-W
Abstract
Three isoforms of platelet-derived growth factors (PDGFs) composing of AA AB and BB chains all exhibited angiogenic activity in a dose-depen dent manner in an in vivo assay system involving the chorioallantoic m embrane of chick embryo. The order of potency was BB>AB=AA. They, howe ver, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest the pos sibility that three PDGF isoforms are indirect angiogenic factors.