LOCALIZATION OF PRESENILIN-1 MESSENGER-RNA IN RAT-BRAIN

WE examined the regional and cellular distribution of presenilin-1 gen e expression in the rat brain by in situ hybridization. Microscopic an alysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hipp ocampus, thalamic nuclei and the cerebellar granular layer. The expres sion of presenilin-1 is mostly neuronal: only a weak hybridization sig nal was found in the corpus callosum and in the astrocytoma cell lines U373MG and U138MG.