SYMPTOMATIC IGG3 DEFICIENCY SUCCESSFULLY TREATED WITH INTRAVENOUS IMMUNOGLOBULIN THERAPY

We report the case of a 35 year old female who presented with an 8 yea r history of repeated upper respiratory tract infection, lymphadenopat hy and sinusitis associated with IgG3 deficiency. Courses of monthly i ntravenous immunoglobulin therapy (0.4 g/kg) resulted in a dramatic cl inical improvement on three different occasions. We suggest that inves tigation of adults with features of immunosuppression, despite normal levels of total IgG, should include IgG3 subclass analysis and that sy mptomatic patients should be given a trial of immunoglobulin replaceme nt therapy.